Acute toxicology

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J. Invest. Dermatol. 50, 19. Marzulli, F. , and Maibach, H. I. (1975). The rabbit as a model for evaluating the skin irritants: A comparison of results obtained on animals and man using repeated skin exposures. Fd. Cosmet. Toxicol. 13, 533-540. Mathias, C. G. T. (1983). Clinical and experimental aspects of cutaneous irritation. In Dermatoxicology (F. M. Margulli and H. T. ), pp. 167-183. Hemisphere, New York. , and Blank, H. (1958). Location and reformation of epithelial barrier to water vapor.

Methuen, London. CHAPTER 3 Tests for Dermal Irritation and Corrosion Evaluation of materials for their potential to cause dermal irritation and corrosion due to acute contact has been common for industrial chemicals, cosmetics, agricultural chemicals, and consumer products since at least the 1930s (generally, pharmaceuticals are only evaluated for dermal effects if they are to be administered topically--and then by repeat exposure tests, which will not be addressed here). As with acute eye irritation tests, one of the earliest formal publications of a test method (though others were used) was that of Draize et al.

Vol. 7, pp. 183-189. Liebert, New York. Nixon, G. , Tyson, C. , and Wertz, W. C. (1975). Interspecies comparisons of skin irritancy. Appl. Pharmacol. 31,481-590. Organization for Economic Cooperation and Development (OECD) (1992). OECD guidelines for testing of chemicals, Section 404, Acute Dermal Irritation/Corrosion, adopted July 17, 1992, Paris. , Maibach, H. , and Burkhalter, A. (1985). Mechanisms of chemically induced skin irritation. Toxicol. Appl. Pharmacol. 81,476-490. , Maibach, H. , and Akers, W.

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