Annual Update in Intensive Care and Emergency Medicine 2016 by Jean-Louis Vincent

By Jean-Louis Vincent

The yearly replace compiles the newest advancements in experimental and scientific examine and perform in a single complete reference ebook. The chapters are written through good well-known specialists within the box of extensive care and emergency drugs. it really is addressed to everybody keen on inner drugs, anesthesia, surgical procedure, pediatrics, in depth care and emergency drugs.

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The Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) was the first coronavirus identified to cause widespread outbreaks of critical illness. It caused a worldwide outbreak during the winter of 2002–2003, eventually leading to 8096 confirmed cases, including 774 deaths [7]. The SARS epidemic was contained in 2003 [7]. SARS-CoV belongs to lineage B of the betacoronavirus [8], whereas MERS-CoV belongs to lineage C of the same genus. MERSCoV enters cells via a common receptor, the dipeptidyl peptidase-4 (DPP4), also known as CD26, and replicates in bronchial, bronchiolar and type I and II alveolar epithelial cells [9, 10].

Int J Infect Dis 29:307–308 13. Eckerle I, Muller MA, Kallies S, Gotthardt DN, Drosten C (2013) In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection. Virol J 10:359 14. Drosten C, Seilmaier M, Corman VM et al (2013) Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection. Lancet Infect Dis 13:745– 751 15. Azhar EI, El-Kafrawy SA, Farraj SA et al (2014) Evidence for camel-to-human transmission of MERS coronavirus.

Infection Prevention and Control Because of the risk of transmission within the healthcare setting, appropriate patient isolation and strict implementation of infection prevention and control measures are crucial in the management of MERS-CoV cases. For suspected cases, the WHO recommends droplet and contact precautions [30]. , aspiration or open suctioning of respiratory tract, intubation, bronchoscopy, cardiopulmonary resuscitation) airborne precautions should be additionally applied [30]. The Centers for Disease Control and Prevention (CDC) recommends that droplet precautions should be added to standard precautions when providing care to all patients with symptoms of acute respiratory infection and that a Critically Ill Patients with Middle East Respiratory Syndrome Coronavirus Infection 41 suspected or confirmed MERS-CoV case should be isolated in an airborne infection isolation room that is constructed and maintained according to current guidelines [31].

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